In recent years, certain cell surface markers have been reported as CSC markers in digestive system cancers, with high expression of these markers usually an indicator of poor prognosis. It has been reported that a small subpopulation of cells, called cancer stem cells (CSCs), dominate the initiation, progression, relapse and metastasis of cancer. Although treatments for digestive system cancers have been developing rapidly, these cancers, especially pancreatic and colorectal cancer, are still responsible for a number of deaths.
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